Detalhe da pesquisa
1.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
2.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
3.
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency.
Drug Resist Updat
; 67: 100932, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706533
4.
Biological plasticity rescues target activity in CRISPR knock outs.
Nat Methods
; 16(11): 1087-1093, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31659326
5.
Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum.
Nucleic Acids Res
; 47(22): 11574-11588, 2019 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31728527
6.
Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs.
Anal Chem
; 92(17): 11851-11859, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32867487
7.
Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space.
Mol Pharm
; 17(2): 488-498, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31834804
8.
Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.
Nat Methods
; 12(12): 1129-31, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26524241
9.
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Nature
; 488(7411): 404-8, 2012 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22842901
10.
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Acta Neuropathol
; 133(5): 731-749, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28083634
11.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol
; 11(3): 189-91, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25622091
12.
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
Nat Chem Biol
; 11(11): 878-86, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26436839
13.
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Nature
; 478(7370): 529-33, 2011 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21964340
14.
Kruidenier et al. reply.
Nature
; 514(7520): E2, 2014 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25279927
15.
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
Nat Chem Biol
; 8(6): 576-82, 2012 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22544264
16.
Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens.
Genome Biol
; 25(1): 42, 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38308274
17.
Mass spectrometry approaches to monitor protein-drug interactions.
Methods
; 57(4): 430-40, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22687620
18.
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells.
Elife
; 122023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37073955
19.
Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics.
BMC Cancer
; 12: 38, 2012 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22277058
20.
Chemoproteomic approaches to drug target identification and drug profiling.
Bioorg Med Chem
; 20(6): 1973-8, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22130419